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What causes pain?
No one completely understands how pain works. Pain is really something
you feel in your brain. For example, let's say you hit your finger with a
hammer. The part of your finger that is damaged has nerve endings in it.
These are little detectors in your joints and your skin that feel things
like heat, touch, vibrating, and, of course, big crushing shocks like being
hit with a hammer. There are different receptors for each of these types of
sensations. The damaged tissue in your finger also releases some chemicals
that make those nerve endings register the crushing shock even stronger,
like turning up the volume on your stereo so you can hear it better. Some of
these chemicals are prostaglandins, and working cells in the damaged tissues
make these chemicals using an enzyme called cyclooxygenase-2 (COX-2).
There have been chemicals, both natural and synthetic, used for centuries
to treat pain. One of the first and most influential physicians,
Hippocrates, wrote about a bitter powder extracted from willow bark that
could ease aches and pains and reduce fevers as long ago as the fifth
century B.C. The active constituent in willow bark is known as salacin. This
chemical can be converted (changed) by the body after it is eaten to another
chemical, salicyclic acid.